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Article

Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy.

The Journal of biological chemistry - 8 Mar 2002

Yanazume Tetsuhiko, Hasegawa Koji, Wada Hiromichi, Morimoto Tatsuya, Abe Mitsuru, Kawamura Teruhisa, Sasayama Shigetake

Abstract excerpt

The low molecular weight GTPase Rho mediates a variety of cytoskeleton-dependent cell functions and stretch- and G(q) protein-induced hypertrophic responses in cardiac myocytes. Although ROCK, one of Rho's effectors, has been suggested to mediate hypertrophic signals, the relationship of Rho/ROCK with downstream signals is unknown. A zinc finger transcription factor, GATA-4, is activated by extracellular...

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Identifiers

PMID: 11739382
DOI: 10.1074/jbc.M107924200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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