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Article

Ral GDP dissociation stimulator and Ral GTPase are involved in myocardial hypertrophy.

Hypertension (Dallas, Tex. : 1979) - 1 Apr 2003

Kawai Miki, Kawashima Seinosuke, Sakoda Tsuyoshi, Toh Ryuji, Kikuchi Akira, Yamauchi-Takihara Keiko, Kunisada Keita, Yokoyama Mitsuhiro

Abstract excerpt

Ras-related GTPase (Ral) is converted to the GTP-bound form by Ral GDP dissociation stimulator (Ral-GDS), a putative effector protein of Ras. Although a number of studies indicate that Ras induces cardiac hypertrophy, the functional role of Ral-GDS/Ral signaling pathway is as yet unknown in cardiac myocytes. We investigated the role of the Ral-GDS/Ral pathway in cardiac hypertrophy. Transfection of Ral-GDS and...

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Identifiers

PMID: 12642511
DOI: 10.1161/01.HYP.0000063884.36641.63

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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