Article
Estrogen-related receptor gamma induces cardiac hypertrophy by activating GATA4.
Journal of molecular and cellular cardiology - 1 Dec 2013
Kwon Duk-Hwa, Eom Gwang Hyeon, Kee Hae Jin, Nam Yoon Seok, Cho Young Kuk, Kim Don-Kyu, Koo Ja Young, Kim Hyung-Seok, Nam Kwang-Il, Kim Kyung Keun, Lee In-Kyu, Park Seung Bum, Choi Hueng-Sik, Kook Hyun
Abstract excerpt
Estrogen-related receptor gamma (ERRγ) is an orphan nuclear receptor that has biological roles mainly in metabolism and that controls metabolic switching in perinatal heart. In adult heart diseases, however, the functional roles of ERRγ have not yet been elucidated. In the present study, we aimed to characterize the role of ERRγ in cardiac hypertrophy. The functional roles of ERRγ in the development of cardiac...
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