Article
A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival.
Neuron - 6 Dec 2001
Rattner A, Smallwood P M, Williams J, Cooke C, Savchenko A, Lyubarsky A, Pugh E N, Nathans J
Abstract excerpt
A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing. prCAD is expressed only in retinal photoreceptors, and the prCAD protein is localized to the base of the outer segment of both rods and cones. In prCAD(-/-) mice, outer segments are disorganized and fragmented, and there is progressive death of photoreceptor cells. prCAD is unlikely to be...
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