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Article

CDHR1-associated retinal degeneration: Clinical phenotypes and therapeutic approaches.

Progress in retinal and eye research - 1 Sept 2026

Narayan Akshay R, Charbel Issa Peter, Yusuf Imran H, MacLaren Robert E

Abstract excerpt

CDHR1 is a recently identified cause of autosomal recessive retinal degeneration manifesting as three distinct clinical phenotypes: macular dystrophy, cone-rod dystrophy or retinitis pigmentosa. In this review, we summarise the discovery and characterisation of CDHR1, clinical phenotypes, natural history and therapeutic approaches including gene supplementation and CRISPR gene editing. CDHR1 is a non-classical...

Read the complete abstract on PubMed

Topics

Humans
Animals
Phenotype
Genetic Therapy
Cadherin Related Proteins
Cadherins
Retinal Degeneration

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Therapy Agents

Nerve Tissue Proteins

Source

Identifiers

PMID: 42562233
DOI: 10.1016/j.preteyeres.2026.101508

Genes

CDHR1
ABCA4
GUCY2D
PRPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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