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Article

Reversible and specific extracellular antagonism of receptor-histidine kinase signaling.

The Journal of biological chemistry - 22 Feb 2002

Lyon Gholson J, Wright Jesse S, Christopoulos Arthur, Novick Richard P, Muir Tom W

Abstract excerpt

Staphylococcal pathogenesis is regulated by a two-component quorum-sensing system, agr, activated by a self-coded autoinducing peptide (AIP). The agr system is widely divergent and is unique in that variant AIPs cross-inhibit agr activation in heterologous combinations. Cross-inhibition, but not self-activation, is widely tolerant of structural diversity in the AIPs so that these two processes must involve...

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Share to Histidine Kinase
Share to Peptides, Cyclic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Cell Surface

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Source

Identifiers

PMID: 11733525
DOI: 10.1074/jbc.M109989200

Genes

AIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reversible and specific extracellular antagonism of receptor-histidine kinase signaling.PMID 11733525Read ↗

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