Article
Influence of the AgrC-AgrA complex on the response time of Staphylococcus aureus quorum sensing.
Journal of bacteriology - 1 Aug 2014
Srivastava Sandeep K, Rajasree Kalagiri, Fasim Aneesa, Arakere Gayathri, Gopal Balasubramanian
Abstract excerpt
The Staphylococcus aureus agr quorum-sensing system plays a major role in the transition from the persistent to the virulent phenotype. S. aureus agr type I to IV strains are characterized by mutations in the sensor domain of the histidine kinase AgrC and differences in the sequences of the secreted autoinducing peptides (AIP). Here we demonstrate that interactions between the cytosolic domain of AgrC (AgrCCyto)...
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