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Article

Nucleotide diversity and haplotype structure of the human angiotensinogen gene in two populations.

American journal of human genetics - 1 Jan 2002

Nakajima Toshiaki, Jorde Lynn B, Ishigami Tomoaki, Umemura Satoshi, Emi Mitsuru, Lalouel Jean-Marc, Inoue Ituro

Abstract excerpt

Variation in the angiotensinogen gene, AGT, has been associated with variation in plasma angiotensinogen levels. In addition, the T235M polymorphism in the AGT product is associated with an increased risk of essential hypertension in multiple populations, making AGT a good example of a quantitative-trait locus underlying susceptibility to a common disease. To better understand genetic variation in AGT, we...

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Identifiers

PMID: 11731937
DOI: 10.1086/338454
PMCID: PMC384882

Genes

AGT

Variants

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