Article
Haplotypes of angiotensinogen in essential hypertension.
American journal of human genetics - 1 Jun 1997
Jeunemaitre X, Inoue I, Williams C, Charru A, Tichet J, Powers M, Sharma A M, Gimenez-Roqueplo A P, Hata A, Corvol P, Lalouel J M
Abstract excerpt
The M235T polymorphism of the angiotensinogen gene (AGT) has been associated with essential and pregnancy-induced hypertension. Generation of haplotypes can help to resolve whether the T235 allele itself predisposes to the development of hypertension or acts as a marker of an unknown causal molecular variant. We identified 10 diallelic polymorphisms at the AGT locus and genotyped both a series of 477 probands of...
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