Article
Linkage disequilibrium and haplotype diversity in the genes of the renin-angiotensin system: findings from the family blood pressure program.
Genome research - 1 Feb 2003
Zhu Xiaofeng, Yan Denise, Cooper Richard S, Luke Amy, Ikeda Morna A, Chang Yen-Pei C, Weder Alan, Chakravarti Aravinda
Abstract excerpt
Association studies of candidate genes with complex traits have generally used one or a few single nucleotide polymorphisms (SNPs), although variation in the extent of linkage disequilibrium (LD) within genes markedly influences the sensitivity and precision of association studies. The extent of LD and the underlying haplotype structure for most candidate genes are still unavailable. We sampled 193 blacks...
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