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Article

Natural selection and population history in the human angiotensinogen gene (AGT): 736 complete AGT sequences in chromosomes from around the world.

American journal of human genetics - 1 May 2004

Nakajima Toshiaki, Wooding Stephen, Sakagami Takuro, Emi Mitsuru, Tokunaga Katsushi, Tamiya Gen, Ishigami Tomoaki, Umemura Satoshi, Munkhbat Batmunkh, Jin Feng, Guan-Jun Jia, Hayasaka Ikuo, Ishida Takafumi, Saitou Naruya, Pavelka Karel, Lalouel Jean-Marc, Jorde Lynn B, Inoue Ituro

Abstract excerpt

Several lines of evidence suggest that patterns of genetic variability in the human angiotensinogen gene (AGT) contribute to phenotypic variability in human hypertension. The A(-6) promoter variant of AGT is associated with higher plasma angiotensinogen levels and increased risk of essential hypertension. The geographic distribution of the A(-6) variant leads to the intriguing hypothesis that the G(-6) promoter...

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Identifiers

PMID: 15077204
DOI: 10.1086/420793
PMCID: PMC1181984

Genes

AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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