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Article

A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin.

Journal of advanced research - 1 Mar 2021

Breitinger Ulrike, Weinländer Kristina, Pechmann Yvonne, Langlhofer Georg, Enz Ralf, Becker Cord-Michael, Sticht Heinrich, Kneussel Matthias, Villmann Carmen, Breitinger Hans-Georg

Abstract excerpt

Introduction: The inhibitory glycine receptor (GlyR), a mediator of fast synaptic inhibition, is located and held at neuronal synapses through the anchoring proteins gephyrin and collybistin. Stable localization of neurotransmitter receptors is essential for synaptic function. In case of GlyRs, only beta subunits were known until now to mediate synaptic anchoring. Objectives: We identified a poly-proline II helix...

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Identifiers

PMID: 33842008
DOI: 10.1016/j.jare.2020.09.009
PMCID: PMC8020344

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