Article
Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein.
Neuron - 1 Jun 1992
Prior P, Schmitt B, Grenningloh G, Pribilla I, Multhaup G, Beyreuther K, Maulet Y, Werner P, Langosch D, Kirsch J
Abstract excerpt
A 93 kd polypeptide associated with the mammalian inhibitory glycine receptor (GlyR) is localized at central synapses and binds with high affinity to polymerized tubulin. This protein, named gephyrin (from the Greek gamma epsilon phi upsilon rho alpha, bridge), is thought to anchor the GlyR to subsynaptic microtubules. Here we report its primary structure deduced from cDNA and show that corresponding transcripts...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Carrier Proteins
- Cell Line
- DNA
- DNA, Recombinant
- Genetic Variation
- Kidney
- Membrane Proteins
- Molecular Sequence Data