Article
Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase.
Cancer cell - 9 Sept 2013
Petersen Nikolaj H T, Olsen Ole D, Groth-Pedersen Line, Ellegaard Anne-Marie, Bilgin Mesut, Redmer Susanne, Ostenfeld Marie S, Ulanet Danielle, Dovmark Tobias H, Lønborg Andreas, Vindeløv Signe D, Hanahan Douglas, Arenz Christoph, Ejsing Christer S, Kirkegaard Thomas, Rohde Mikkel, Nylandsted Jesper, Jäättelä Marja
Abstract excerpt
Lysosomal membrane permeabilization and subsequent cell death may prove useful in cancer treatment, provided that cancer cell lysosomes can be specifically targeted. Here, we identify acid sphingomyelinase (ASM) inhibition as a selective means to destabilize cancer cell lysosomes. Lysosome-destabilizing experimental anticancer agent siramesine inhibits ASM by interfering with the binding of ASM to its essential...
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