Article
Phospholipid scramblase activation pathways in lymphocytes.
Biochemistry - 10 Jul 2001
Williamson P, Christie A, Kohlin T, Schlegel R A, Comfurius P, Harmsma M, Zwaal R F, Bevers E M
Abstract excerpt
In erythrocytes and platelets, activation of a nonspecific lipid flipsite termed the scramblase allows rapid, bidirectional transbilayer movement of all types of phospholipids. When applied to lymphoid cells, scramblase assays reveal a similar activity, with scrambling rates intermediate between those seen in platelets and erythrocytes. Scrambling activity initiated in lymphoid cells by elevation of intracellular...
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