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Article

Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast.

The EMBO journal - 3 Dec 2001

Friant S, Lombardi R, Schmelzle T, Hall M N, Riezman H

Abstract excerpt

In yeast, sphingoid base synthesis is required for the internalization step of endocytosis and organization of the actin cytoskeleton. We show that overexpression of either one of the two kinases Pkh1p or Pkh2p, that are homologous to mammalian 3-phosphoinositide-dependent kinase-1 (PDK1), can specifically suppress the sphingoid base synthesis requirement for endocytosis. Pkh1p and Pkh2p have an overlapping...

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Identifiers

PMID: 11726514
DOI: 10.1093/emboj/20.23.6783
PMCID: PMC125749

Genes

PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast.PMID 11726514Read ↗

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