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Article

Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae.

The EMBO journal - 15 Jun 2000

Zanolari B, Friant S, Funato K, Sütterlin C, Stevenson B J, Riezman H

Abstract excerpt

The internalization step of endocytosis in yeast requires actin and sterols for maximum efficiency. In addition, many receptors and plasma membrane proteins must be phosphorylated and ubiquitylated prior to internalization. The Saccharomyces cerevisiae end8-1 mutant is allelic to lcb1, a mutant defective in the first step of sphingoid base synthesis. Upon arrest of sphingoid base synthesis a rapid block in...

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Identifiers

PMID: 10856228
DOI: 10.1093/emboj/19.12.2824
PMCID: PMC203373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae.PMID 10856228Read ↗

Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis.Semantic proximity Read ↗

Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast.Semantic proximity Read ↗

The uracil transporter Fur4p associates with lipid rafts.Semantic proximity Read ↗

The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases.Semantic proximity Read ↗

Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Elevation of endogenous sphingolipid long-chain base phosphates kills Saccharomyces cerevisiae cells.Semantic proximity Read ↗

An Abp1-dependent route of endocytosis functions when the classical endocytic pathway in yeast is inhibited.Semantic proximity Read ↗

Sphingoid base synthesis is required for oligomerization and cell surface stability of the yeast plasma membrane ATPase, Pma1.Semantic proximity Read ↗

Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated.Semantic proximity Read ↗

Specific sterols required for the internalization step of endocytosis in yeast.Semantic proximity Read ↗

The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast.Semantic proximity Read ↗

Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids.Semantic proximity Read ↗

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