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Article

The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast.

The Journal of cell biology - 21 Jan 2002

deHart Amy K A, Schnell Joshua D, Allen Damian A, Hicke Linda

Abstract excerpt

Internalization of activated signaling receptors by endocytosis is one way cells downregulate extracellular signals. Like many signaling receptors, the yeast alpha-factor pheromone receptor is downregulated by hyperphosphorylation, ubiquitination, and subsequent internalization and degradation in the lysosome-like vacuole. In a screen to detect proteins involved in ubiquitin-dependent receptor internalization, we...

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Source

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Identifiers

PMID: 11807089
DOI: 10.1083/jcb.200107135
PMCID: PMC2199229

Genes

PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast.PMID 11807089Read ↗

Cytoplasmic tail phosphorylation of the alpha-factor receptor is required for its ubiquitination and internalization.Semantic proximity Read ↗

Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast.Semantic proximity Read ↗

The requirement for the hydrophobic motif phosphorylation of Ypk1 in yeast differs depending on the downstream events, including endocytosis, cell growth, and resistance to a sphingolipid biosynthesis inhibitor, ISP-1.Semantic proximity Read ↗

Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation.Semantic proximity Read ↗

Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK.Semantic proximity Read ↗

The yeast phosphatidylinositol-4-OH kinase pik1 regulates secretion at the Golgi.Semantic proximity Read ↗

Akr1p and the type I casein kinases act prior to the ubiquitination step of yeast endocytosis: Akr1p is required for kinase localization to the plasma membrane.Semantic proximity Read ↗

Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.Semantic proximity Read ↗

Ypk1, the yeast orthologue of the human serum- and glucocorticoid-induced kinase, is required for efficient uptake of fatty acids.Semantic proximity Read ↗

The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors.Semantic proximity Read ↗

Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis.Semantic proximity Read ↗

[YPK1 overexpression resulted salt stress hypersensitivity in Saccharomyces cerevisiae is dependent on TOR1].Semantic proximity Read ↗

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