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Article

Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase Pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth.

Molecular biology of the cell - 1 Mar 2008

Demmel Lars, Beck Mike, Klose Christian, Schlaitz Anne-Lore, Gloor Yvonne, Hsu Peggy P, Havlis Jan, Shevchenko Andrej, Krause Eberhard, Kalaidzidis Yannis, Walch-Solimena Christiane

Abstract excerpt

The yeast phosphatidylinositol 4-kinase Pik1p is essential for proliferation, and it controls Golgi homeostasis and transport of newly synthesized proteins from this compartment. At the Golgi, phosphatidylinositol 4-phosphate recruits multiple cytosolic effectors involved in formation of post-Golgi transport vesicles. A second pool of catalytically active Pik1p localizes to the nucleus. The physiological...

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Identifiers

PMID: 18172025
DOI: 10.1091/mbc.e07-02-0134
PMCID: PMC2262966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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