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Article

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways.

Molecular biology of the cell - 1 Jun 2012

Sun Yidi, Miao Yansong, Yamane Yukari, Zhang Chao, Shokat Kevan M, Takematsu Hiromu, Kozutsumi Yasunori, Drubin David G

Abstract excerpt

Sphingoid intermediates accumulate in response to a variety of stresses, including heat, and trigger cellular responses. However, the mechanism by which stress affects sphingolipid biosynthesis has yet to be identified. Recent studies in yeast suggest that sphingolipid biosynthesis is regulated through phosphorylation of the Orm proteins, which in humans are potential risk factors for childhood asthma. Here we...

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Identifiers

PMID: 22535525
DOI: 10.1091/mbc.E12-03-0209
PMCID: PMC3374756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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