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Article

Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis.

The EMBO journal - 15 Jun 2000

Friant S, Zanolari B, Riezman H

Abstract excerpt

Lipids have been implicated in signal transduction and in several stages of membrane trafficking, but these two functions have not been functionally linked. In yeast, sphingoid base synthesis is required for the internalization step of endocytosis and organization of the actin cytoskeleton. We show that inactivation of a protein phosphatase 2A (PP2A) or overexpression of one of two kinases, Yck2p or Pkc1p, can...

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Identifiers

PMID: 10856229
DOI: 10.1093/emboj/19.12.2834
PMCID: PMC203374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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