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Article

Sphingoid base synthesis is required for oligomerization and cell surface stability of the yeast plasma membrane ATPase, Pma1.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 2002

Wang Qiongqing, Chang Amy

Abstract excerpt

The plasma membrane H(+)-ATPase, Pma1, is an essential and long-lived integral membrane protein. Previous work has demonstrated that the Pma1-D378N mutant is a substrate for endoplasmic reticulum (ER)-associated degradation and causes a dominant negative effect on cell growth by preventing ER export of wild-type Pma1. We now show that Pma1-D378N is ubiquitylated, and it heterooligomerizes with wild-type Pma1,...

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Identifiers

PMID: 12244215
DOI: 10.1073/pnas.202115499
PMCID: PMC130549

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Sphingoid base synthesis is required for oligomerization and cell surface stability of the yeast plasma membrane ATPase, Pma1.PMID 12244215Read ↗

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