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Article

Calreticulin and calnexin in the endoplasmic reticulum are important for phagocytosis.

The EMBO journal - 3 Dec 2001

Müller-Taubenberger A, Lupas A N, Li H, Ecke M, Simmeth E, Gerisch G

Abstract excerpt

Calreticulin and calnexin are Ca2+-binding proteins with chaperone activity in the endoplasmic reticulum. These proteins have been eliminated by gene replacement in Dictyostelium, the only microorganism known to harbor both proteins; family members in Dictyostelium are located at the base of phylogenetic trees. A dramatic decline in the rate of phagocytosis was observed in double mutants lacking calreticulin and...

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Identifiers

PMID: 11726513
DOI: 10.1093/emboj/20.23.6772
PMCID: PMC125758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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