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Article

Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative.

Neurology - 27 Nov 2001

Desaphy J F, De Luca A, Tortorella P, De Vito D, George A L, Conte Camerino D

Abstract excerpt

BACKGROUND: Myotonia and periodic paralysis caused by sodium channel mutations show variable responses to the anti-myotonic drug mexiletine. OBJECTIVE: To investigate whether variability among sodium channel mutants results from differences in drug binding affinity or in channel gating. METHODS: Whole-cell sodium currents (I(Na)) were recorded in tsA201 cells expressing human wild-type (WT) and mutant skeletal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Paralyses, Familial Periodic

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Source

Identifiers

PMID: 11723275
DOI: 10.1212/wnl.57.10.1849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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