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Article

Different effects of mexiletine on two mutant sodium channels causing paramyotonia congenita and hyperkalemic periodic paralysis.

Neuromuscular disorders : NMD - 1 Jan 2000

Weckbecker K, Würz A, Mohammadi B, Mansuroglu T, George A L, Lerche H, Dengler R, Lehmann-Horn F, Mitrovic N

Abstract excerpt

Effects of the antiarrhythmic and antimyotonic drug mexiletine were studied on two sodium channel mutants causing paramyotonia congenita (R1448H) and an overlap paramyotonic and hyperkalemic paralytic syndrome (M1360V). Channels were expressed in human embryonic kidney cells and studied electrophysiologically, using the whole-cell patch-clamp technique. Compared to the wild-type, channel, both mutants showed...

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PMID: 10677861
DOI: 10.1016/s0960-8966(99)00060-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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