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Article

Ranolazine block of human Na v 1.4 sodium channels and paramyotonia congenita mutants.

Channels (Austin, Tex.) - 1 Jan 2000

El-Bizri Nesrine, Kahlig Kristopher M, Shyrock John C, George Alfred L, Belardinelli Luiz, Rajamani Sridharan

Abstract excerpt

The antianginal drug ranolazine exerts voltage- and use-dependent block (UDB) of several Na+ channel isoforms, including Na(v) 1.4. We hypothesized that ranolazine will similarly inhibit the paramyotonia congenita Na(v) 1.4 gain-of-function mutations, R1448C, R1448H, and R1448P that are associated with repetitive action potential firing. Whole-cell Na+ current (I(Na)) was recorded from HEK293 cells expressing the...

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PMID: 21317558
DOI: 10.4161/chan.5.2.14851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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