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Article

Preferred mexiletine block of human sodium channels with IVS4 mutations and its pH-dependence.

Pharmacogenetics and genomics - 1 Apr 2005

Mohammadi Bahram, Jurkat-Rott Karin, Alekov Alexi, Dengler Reinhard, Bufler Johannes, Lehmann-Horn Frank

Abstract excerpt

The effects of extracellular pH (6.2, 7.4 and 8.2) and 0.1 mM mexiletine, a channel blocker of the lidocaine type, are studied on two mutations of the fourth voltage sensor of the Nav1.4 sodium channel, R1448H/C. The fast inactivated channel state to which mexiletine preferentially binds is destabilized by the mutations. By contrast to the expected low response of R1448H/C carriers, mexiletine is particularly...

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PMID: 15864116
DOI: 10.1097/01213011-200504000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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