Article
Phenol derivatives accelerate inactivation kinetics in one inactivation-deficient mutant human skeletal muscle Na(+) channel.
European journal of pharmacology - 23 Mar 2001
Haeseler G, Piepenbrink A, Bufler J, Dengler R, Hecker H, Aronson J, Piepenbrock S, Leuwer M
Abstract excerpt
Altered inactivation kinetics in skeletal muscle Na(+) channels due to mutations in the encoding gene are causal for the alterations in muscle excitability in nondystrophic myotonia. Na(+) channel blockers like lidocaine and mexiletine, suggested for therapy of myotonia, do not reconstitute inactivation in channels with defective inactivation in vitro. We examined the effects of four methylated and/or halogenated...
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