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Article

Voltage-dependent blockade of normal and mutant muscle sodium channels by benzylalcohol.

British journal of pharmacology - 1 Jul 2000

Haeseler G, Mamarvar M, Bufler J, Dengler R, Hecker H, Aronson J K, Piepenbrock S, Leuwer M

Abstract excerpt

1. We studied the effects of benzylalcohol on heterologously expressed wild type (WT), paramyotonia congenita (R1448H) and hyperkalaemic periodic paralysis (M1360V) mutant alpha-subunits of human skeletal muscle sodium channels. 2. Benzylalcohol blocked rested channels at -150 mV membrane potential, with an ECR(50) of 5.3 mM in wild type, 5.1 mM in R1448H, and 6.2 mM in M1360V. When blockade was assessed at -100...

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Identifiers

PMID: 10903972
DOI: 10.1038/sj.bjp.0703447
PMCID: PMC1572205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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