Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels.

The Journal of physiology - 1 Feb 2004

Wang Ging Kuo, Russell Corinna, Wang Sho-Ya

Abstract excerpt

Mexiletine is a class 1b antiarrhythmic drug used for ventricular arrhythmias but is also found to be effective for paramyotonia congenita, potassium-aggravated myotonia, long QT-3 syndrome, and neuropathic pain. This drug elicits tonic block of Na(+) channels when cells are stimulated infrequently and produces additional use-dependent block during repetitive pulses. We examined the state-dependent block by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Arrhythmia Agents
Share to Binding, Competitive
Share to Electric Conductivity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Proteins

Share to NAV1.4 Voltage-Gated Sodium Channel

Share to Patch-Clamp Techniques

Share to Sodium Channel Blockers

Share to Sodium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 14608007
DOI: 10.1113/jphysiol.2003.054973
PMCID: PMC1664796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels.PMID 14608007Read ↗

Ranolazine block of human Na v 1.4 sodium channels and paramyotonia congenita mutants.Semantic proximity Read ↗

Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative.Semantic proximity Read ↗

Different effects of mexiletine on two mutant sodium channels causing paramyotonia congenita and hyperkalemic periodic paralysis.Semantic proximity Read ↗

Inactivation-deficient human skeletal muscle Na+ channels (hNav1.4-L443C/A444W) in stably transfected HEK-293 cells.Semantic proximity Read ↗

State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.Semantic proximity Read ↗

Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block.Semantic proximity Read ↗

Phenol derivatives accelerate inactivation kinetics in one inactivation-deficient mutant human skeletal muscle Na(+) channel.Semantic proximity Read ↗

Two human paramyotonia congenita mutations have opposite effects on lidocaine block of Na+ channels expressed in a mammalian cell line.Semantic proximity Read ↗

Towards development of Nav1.7 channel modulators for pain treatment: A comparison of mexiletine effect in two cell models by automated patch clampSemantic proximity Read ↗

Voltage-dependent blockade of normal and mutant muscle sodium channels by benzylalcohol.Semantic proximity Read ↗

Effects of temperature and mexiletine on the F1473S Na+ channel mutation causing paramyotonia congenita.Semantic proximity Read ↗

Long-term Safety and Efficacy of Mexiletine for Patients With Skeletal Muscle Channelopathies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.