Article
Case-control study and meta-analysis of low density lipoprotein receptor-related protein gene exon 3 polymorphism in Alzheimer's disease.
Neuroscience letters - 4 Dec 2001
Sánchez-Guerra M, Combarros O, Infante J, Llorca J, Berciano J, Fontalba A, Fernández-Luna J L, Peña N, Fernández-Viadero C
Abstract excerpt
The low density lipoprotein receptor-related protein (LRP) may influence both the clearance and the production of beta-amyloid peptide and thus plays a role in Alzheimer's disease (AD) pathogenesis. Previous studies, although inconsistent, have suggested that the LRP exon 3 CC genotype contributes to the risk of AD. A case-control study utilizing a clinically well-defined group of 305 sporadic AD patients and 304...
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