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Functional Analyses of Human Apolipoprotein CII by Site-directed Mutagenesis

1 Feb 2002

Abstract excerpt

Apolipoprotein CII (apoCII) activates lipoprotein lipase (LPL). Seven residues, located on one face of a model alpha-helix spanning residues 59-75, are fully conserved in apoCII from ten different animal species. We have mutated these residues one by one. Substitution of Ala(59) by glycine, or Thr(62) and Gly(65) by alanine did not change the activation, indicating that these residues are outside the LPL-binding...

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PMID: 11719505
DOI: 10.1074/jbc.m105421200

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