Article
An apolipoprotein CII mutation, CIILys19----Thr' identified in patients with hyperlipidemia.
Disease markers - 1 Jan 2000
Hegele R A, Connelly P W, Maguire G F, Huff M W, Leiter L, Wolfe B M, Evans A J, Little J A
Abstract excerpt
Five hyperlipidemic patients (one with Type III, three with Type IV, and one with Type V hyperlipoproteinemia) were found on isoelectric focusing to have both the normal isoform of apolipoprotein CII and a second isoform whose isoelectric point was consistent with a single charge change. The structure of the apolipoprotein CII variant was determined to be the same as normal apolipoprotein CII except for...
Topics
- Adult
- Alleles
- Amino Acid Sequence
- Apolipoprotein C-II
- Apolipoproteins C
- DNA
- Humans
- Hyperlipidemias
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation