Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.

The Journal of clinical investigation - 1 Dec 1995

Li W W, Dammerman M M, Smith J D, Metzger S, Breslow J L, Leff T

Abstract excerpt

Overexpression of plasma apolipoprotein CIII (apo CIII) causes hypertriglyceridemia in transgenic mice. A genetically variant form of the human apo CIII promoter, containing five single base pair changes, has been shown to be associated with severe hypertriglyceridemia in a patient population. In animals and in cultured cells the apo CIII gene is transcriptionally downregulated by insulin. In this study we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Gene Expression Regulation

Share to Genetic Variation

Share to Mice, Transgenic

Source

Open in PubMed Open full text

Identifiers

PMID: 8675624
DOI: 10.1172/JCI118324
PMCID: PMC185964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.PMID 8675624Read ↗

Hypertriglyceridemia and the apolipoprotein CIII gene locus: lack of association with the variant insulin response element in Italian school children.Semantic proximity Read ↗

A variant insulin promoter in non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Hypertriglyceridemia as a Result of Human apo <i>CII</i> Gene Expression in Transgenic MiceSemantic proximity Read ↗

Mutations in the C1 element of the insulin promoter lead to diabetic phenotypes in homozygous mice.Semantic proximity Read ↗

Regulatory gene mutations affecting apolipoprotein gene expression: functions and regulatory behavior of known genes may guide future pharmacogenomic approaches to therapy.Semantic proximity Read ↗

Insulin-Induced Gene 2 Involvement in Human Adipocyte Metabolism and Body Weight RegulationSemantic proximity Read ↗

Genetic heterogeneity in the apolipoprotein C-III promoter and effects of insulin.Semantic proximity Read ↗

The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM.Semantic proximity Read ↗

The apolipoprotein CIII T2854G variants are associated with postprandial triacylglycerol concentrations in normolipidemic Korean men.Semantic proximity Read ↗

The Insulin Gene Promoter: A Simplified NomenclatureSemantic proximity Read ↗

Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells.Semantic proximity Read ↗

In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.