Article
Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.
The Journal of clinical investigation - 1 Dec 1995
Li W W, Dammerman M M, Smith J D, Metzger S, Breslow J L, Leff T
Abstract excerpt
Overexpression of plasma apolipoprotein CIII (apo CIII) causes hypertriglyceridemia in transgenic mice. A genetically variant form of the human apo CIII promoter, containing five single base pair changes, has been shown to be associated with severe hypertriglyceridemia in a patient population. In...
Topics
- Alleles
- Animals
- Apolipoprotein C-III
- Apolipoproteins C
- Base Sequence
- Cell Nucleus
- Chloramphenicol O-Acetyltransferase
- Gene Expression
- Gene Expression Regulation
- Genetic Variation
- Genomic Library
- Humans
- Hyperlipoproteinemia Type IV
- Insulin
- Liver