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Article

Inhibition of ApoCIII

25 Sept 2014

Abstract excerpt

PURPOSE OF REVIEW: Recent large Mendelian randomization studies associate loss-of-function mutations in apolipoprotein CIII (APOCIII) with low levels of triglycerides and decreased incidence of cardiovascular disease. With ample in-vitro and in-vivo evidence for a role of apoCIII in lipoprotein lipase-mediated triglyceride clearance and remnant removal, it is, thus, an attractive target for the treatment of...

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PMID: 25255477
DOI: 10.1097/mol.0000000000000130

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