Article
Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas.
Cancer research - 15 Nov 2001
Wu R, Zhai Y, Fearon E R, Cho K R
Abstract excerpt
Clinical and molecular findings suggest that the four major histological subtypes of ovarian carcinoma (serous, clear cell, mucinous, and endometrioid) likely represent distinct disease entities. Prior studies have shown that ovarian endometrioid adenocarcinomas (OEAs) often carry mutations in the CTNNB1 gene, which encodes beta-catenin, a critical component of the Wnt signaling pathway. However, the nature of...
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