Article
BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer.
Cancer research communications - 1 Aug 2024
Chehade Hussein, Gogoi Radhika, Adzibolosu Nicholas K, Galoforo Sandra, Fehmi Rouba-Ali, Kheil Mira, Fox Alexandra, Kim Seongho, Rattan Ramandeep, Hou Zhanjun, Morris Robert T, Matherly Larry H, Mor Gil, Alvero Ayesha B
Abstract excerpt
The association of BRCA1 and BRCA2 mutations with increased risk for developing epithelial ovarian cancer is well established. However, the observed clinical differences, particularly the improved therapy response and patient survival in BRCA2-mutant patients, are unexplained. Our objective is to identify molecular pathways that are differentially regulated upon the loss of BRCA1 and BRCA2 functions in ovarian...
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