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Article

Abnormalities of the APC/beta-catenin pathway in endometrial cancer.

Oncogene - 14 Nov 2002

Moreno-Bueno Gema, Hardisson David, Sánchez Carolina, Sarrió David, Cassia Raúl, García-Rostán Ginesa, Prat Jaime, Guo Mingzhou, Herman James G, Matías-Guiu Xavier, Esteller Manel, Palacios José

Abstract excerpt

The activation of the APC/beta-catenin signalling pathway due to beta-catenin mutations has been implicated in the development of a subset of endometrial carcinomas (ECs). However, up to 25% of ECs have beta-catenin nuclear accumulation without evidence of beta-catenin mutations, suggesting alter...

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Source

Identifiers

PMID: 12439748
DOI: 10.1038/sj.onc.1205924

Genes

APC
AXIN1
AXIN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12439748-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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