Article
In vivo genotoxicity evaluation of dimethylarsinic acid in MutaMouse.
Mutation research - 15 Jan 2002
Noda Yasuhiro, Suzuki Takayoshi, Kohara Arihiro, Hasegawa Akira, Yotsuyanagi Toshihisa, Hayashi Makoto, Sofuni Toshio, Yamanaka Kenzo, Okada Shoji
Abstract excerpt
Dimethylarsinic acid (DMA) induces DNA damage in the lung by formation of various peroxyl radical species. The present study was conducted to evaluate whether arsenite or its metabolite, DMA, could initiate carcinogenesis via mutagenic DNA lesions in vivo that can be attributed to oxidative damage. A transgenic mouse model, MutaMouse, was used in this study and mutations in the lacZ transgene and in the...
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