Article
Induction of somatic mutations but not methylated DNA adducts in lambdalacZ transgenic mice by dichlorvos.
Cancer letters - 15 Nov 1999
Pletsa V, Steenwinkel M J, van Delft J H, Baan R A, Kyrtopoulos S A
Abstract excerpt
In order to examine the in vivo genotoxic activity of dichlorvos, lambdalacZ transgenic mice (Muta Mouse) were treated i.p. with single (4.4 or 11 mg/kg) or multiple (5 x 11 mg/kg) doses of this agent and sacrificed 4 h or 14 days post-treatment for DNA adduct measurement or mutant frequency analysis, respectively. Neither methylated DNA adducts nor an increase in mutant frequency were detected in the bone...
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