Comparative mutagenicity of 7H-dibenzo[c,g]carbazole and two derivatives in MutaMouse liver and skin.

doi:10.1016/s1383-5718(98)00101-6

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Article

Comparative mutagenicity of 7H-dibenzo[c,g]carbazole and two derivatives in MutaMouse liver and skin.

Mutation research - 11 Sept 1998

Renault D, Tombolan F, Brault D, Périn F, Thybaud V

Abstract excerpt

7H-Dibenzo[c,g]carbazole (DBC) is an environmental pollutant that produces DNA adducts and tumors in mouse liver and skin following subcutaneous injection and topical application. The two synthetic derivatives 5,9-dimethyl-DBC (DMDBC) and N7-methyl-DBC (NMDBC) induce tissue-specific lesions. DNA...

Topics

Administration, Cutaneous
Animals
Carbazoles
Carcinogens
Injections, Subcutaneous
Lac Operon
Liver
Male
Mice
Mutagenicity Tests
Mutation
Skin

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