Article
Mutational spectra of benzo[a]pyrene and MeIQx in rpsL transgenic zebrafish embryos.
Mutation research - 15 Jan 2002
Amanuma Kimiko, Tone Suguru, Saito Hotaka, Shigeoka Tadayoshi, Aoki Yasunobu
Abstract excerpt
To evaluate the rpsL transgenic zebrafish (Brachydanio rerio) mutation assay, we treated the embryos with benzo[a]pyrene (B[a]P) (10 microg/ml) or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) (300 microg/ml) for 16h and determined the mutation spectra. These treatments were previously reported to induce mutant frequencies that were 4.3 and 2.4 times the control value, respectively. In the B[a]P-treated...
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