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Article

Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments.

Nature biotechnology - 1 Jan 2000

Amanuma K, Takeda H, Amanuma H, Aoki Y

Abstract excerpt

We have established a transgenic zebrafish line carrying a shuttle vector plasmid (pML4) for detecting mutagens in aquatic environments. The plasmid contains the rpsL gene of Escherichia coli as a mutational target gene, and the kanamycin-resistance gene for recovering the plasmid from the chromosomal DNA. To evaluate the system, we treated embryos of the transgenic fish with N-ethyl-N-nitrosourea (ENU), which...

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PMID: 10625393
DOI: 10.1038/71938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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