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Article

Position-specific methyl substitution on benzo[a]pyrene drives AHR-dependent fin duplication in zebrafish.

Toxicological sciences : an official journal of the Society of Toxicology - 30 Jan 2026

Morshead Mackenzie L, Truong Lisa, Tanguay Robyn L

Abstract excerpt

Polycyclic aromatic hydrocarbons (PAHs) are a contaminant class characterized by fused aromatic rings, formed through the incomplete combustion of organic materials and petrogenic sources. Despite the abundance and toxicity of alkyl-substituted PAHs, most research and regulation focus on unsubstituted parent PAHs. Alkyl substitution of Benzo[a]pyrene (BaP), one of the most well-studied parent PAHs, drastically...

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Topics

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Share to Animal Fins
Share to Benzo(a)pyrene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to AHR gene

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Share to Receptors, Aryl Hydrocarbon

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Source

Open in PubMed Open full text

Identifiers

PMID: 41264521
DOI: 10.1093/toxsci/kfaf164
PMCID: PMC12826582

Genes

AHR
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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