Article
Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori.
Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2001
Björkholm B, Sjölund M, Falk P G, Berg O G, Engstrand L, Andersson D I
Abstract excerpt
Among the several factors that affect the appearance and spread of acquired antibiotic resistance, the mutation frequency and the biological cost of resistance are of special importance. Measurements of the mutation frequency to rifampicin resistance in Helicobacter pylori strains isolated from dyspeptic patients showed that approximately 1/4 of the isolates had higher mutation frequencies than Enterobacteriaceae...
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