Article
[Biological cost of rifampicin resistance in Helicobacter pylori].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 Jan 2009
Momynaliev K T, Chelysheva V V, Akopian T A, Selezneva O V, Govorun V M
Abstract excerpt
The frequence of mutations in the rifampicin resistant (RIF(r)) clones of microorganisms after adaption to ofloxacin and metronidazole was investigated to estimate the biological cost of H. pylori rifampicin (RIF) resistance. Mutations in rpoB gene responsible for RIF resistance of H. pylori were shown to have biological cost and be compensated by additional mutations in the microorganism genome. Comparison of...
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