Article
Spontaneous mutations that confer antibiotic resistance in Helicobacter pylori.
Antimicrobial agents and chemotherapy - 1 Mar 2001
Wang G, Wilson T J, Jiang Q, Taylor D E
Abstract excerpt
In this study, we systematically examined in vitro frequencies and spectra of the spontaneous mutations in Helicobacter pylori that confer resistance to clarithromycin (Cla(r)), metronidazole (Mtz(r)), amoxicillin (Amx(r)), ciprofloxacin (Cip(r)), and rifampin (Rif(r)). The mutation rate of Rif(r) or Cip(r) determined in a fluctuation assay is 1 x 10(-8) to 2 x 10(-8) per cell per division. In contrast, the...
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