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Article

Role of alpha L beta 2 integrin avidity in transendothelial chemotaxis of mononuclear cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1997

Weber C, Lu C F, Casasnovas J M, Springer T A

Abstract excerpt

The leukocyte integrin alpha L beta 2 (LFA-1) is important in transendothelial migration. Since it is not fully understood how LFA-1 mediates transmigration, we studied the effects of alpha L and beta 2 cytoplasmic domain mutants that alter LFA-1 adhesiveness for intercellular adhesion molecule-1. Monocyte chemotactic protein-1 (MCP-1) induced LFA-1-dependent transendothelial migration of Jurkat and J-beta 2.7...

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Share to Cytoplasm
Share to Dimerization
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

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Share to Protein Binding

Share to Protein Structure, Tertiary

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Source

Identifiers

PMID: 9378985

Genes

SLA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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