Role of alpha L beta 2 integrin avidity in transendothelial chemotaxis of mononuclear cells.

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Article

Role of alpha L beta 2 integrin avidity in transendothelial chemotaxis of mononuclear cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1997

Weber C, Lu C F, Casasnovas J M, Springer T A

Abstract excerpt

The leukocyte integrin alpha L beta 2 (LFA-1) is important in transendothelial migration. Since it is not fully understood how LFA-1 mediates transmigration, we studied the effects of alpha L and beta 2 cytoplasmic domain mutants that alter LFA-1 adhesiveness for intercellular adhesion molecule-1...

Topics

Chemotaxis, Leukocyte
Cytoplasm
Dimerization
Endothelium, Vascular
Humans
Intercellular Adhesion Molecule-1
Jurkat Cells
Leukocytes, Mononuclear
Lymphocyte Function-Associated Antigen-1
Mutation
Protein Binding
Protein Structure, Tertiary
Solubility
Transfection

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Open in PubMed

Identifiers

PMID: 9378985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9378985-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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