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Article

Rolling adhesion of alphaL I domain mutants decorrelated from binding affinity.

Journal of molecular biology - 30 Jun 2006

Pepper Lauren R, Hammer Daniel A, Boder Eric T

Abstract excerpt

Activated lymphocyte function-associated antigen-1 (LFA-1, alphaLbeta2 integrin) found on leukocytes facilitates firm adhesion to endothelial cell layers by binding to intercellular adhesion molecule-1 (ICAM-1), which is up-regulated on endothelial cells at sites of inflammation. Recent work has shown that LFA-1 in a pre-activation, low-affinity state may also be involved in the initial tethering and rolling...

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Identifiers

PMID: 16813834
DOI: 10.1016/j.jmb.2006.04.049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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