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Article

The affinity of integrin alpha(4)beta(1) governs lymphocyte migration.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2001

Rose D M, Grabovsky V, Alon R, Ginsberg M H

Abstract excerpt

The interaction of integrin alpha(4)beta(1) with endothelial VCAM-1 controls the trafficking of lymphocytes from blood into peripheral tissues. Cells actively regulate the affinity of alpha(4)beta(1) for VCAM-1 (activation). To investigate the biological function of alpha(4)beta(1) activation, we isolated Jurkat T cell lines with defective alpha(4)beta(1) activation. Using these cells, we found that...

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Source

Identifiers

PMID: 11509628
DOI: 10.4049/jimmunol.167.5.2824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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